Разработка подсистемы администрирования для системы управления активами предприятия

В компании "Rubius" разрабатывается система управления активами (Enterprise Asset Management) "Rubius DrEAM". В данной системе отсутствует подсистема администрирования, вследствие чего администрирование выполняется вручную с излишними затратами труда времени и денег. Целью выпускной квалификационной работы является разработка подсистемы администрирования, позволяющая настраивать конфигурацию и метаданные, необходимые для функционирования данной системой управления активами. В выпускной квалификационной работе рассматриваются теоретические основы вышеперечисленных систем, проектирование и программная реализация подсистемы администрирования, вопросы социальной ответственности и ресурсоэффективности.In the company "Rubius" an asset management system "Rubius DrEAM" is being developed. In this system there is no subsystem of administration, as a result of which administration is performed manually with unnecessary expenditure of time and money. The goal of the final qualification work is the development of the administration subsystem, which allows configuring the configuration and metadata necessary for the functioning of this asset management system. The final qualification work examines the theoretical foundations of the above systems, design and software implementation of the administration subsystem, issues of social responsibility and resource efficiency

A new automated method for the determination of the Total Antioxidant Capacity (TAC) of human plasma, based on the crocin bleaching assay

BACKGROUND: Antioxidant molecules, which scavenge free radical species to prevent or delay oxidative damage of important macromolecules, membrane lipids and lipoproteins, are prevalent in plasma and other biological fluids. Among them, bilirubin, uric acid and protein thiols are the major endogenous antioxidants, while vitamins C and E, as well as a number of food-derived (poly)aromatic substances, belonging to stilbens, flavonoids and phenolic acids, are the main classes of nutritional antioxidants. Assays for total antioxidant capacity in plasma differ in their type of oxidation source, target and measurement used to detect the oxidized product. METHODS: In the present work we present an automated assay for the estimation of blood total antioxidant capacity (TAC assay), based on the crocin bleaching (oxidation) method. This method was adapted on a modern autoanalyzer, was linear over a wide range of values (0–3 mmol/L), and performed using an end point measurement. RESULTS: The TAC method presented a linear correlation with another automated commercial Total Antioxidant Status (TAS) test. Detection of the interference of different metabolites revealed a significant participation of TAC from uric acid, bilirubin, albumin, a minor interference from ascorbic acid, and no interference from hemoglobin. TAC was not modified by two freeze/thawing cycles, and was stable in samples stored at room temperature for 4 hours. K-EDTA and heparin were the best anticoagulants, while citrate decreased TAC by 20%. Reference values derived from samples of normal blood donors was 1.175 ± 0.007 mmol/L (mean ± SEM), while a diet rich in antioxidants more than doubled this value. CONCLUSIONS: The proposed TAC assay, is fully automated, stable and reliable, and could be of value in the estimation of the AC of plasma. It is further proposed to calculate the antioxidant capacity of plasma after a subtraction of all interference deriving from endogenous and/or exogenous metabolites. The antioxidant capacity of plasma thus calculated can be used as a useful indicator of the antioxidant value of foods and beverages in the daily diet

Glutathione peroxidase, superoxide dismutase and catalase genotypes and activities and the progression of chronic kidney disease

Background. Oxidative stress has been linked to the progression of disease, including chronic kidney disease (CKD). The aim of the present study was to determine the association between single-nucleotide polymorphisms (SNPs) of the antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase and their activities and the progression of CKD